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Our research aims to better understand the mechanisms of cognitive function in the normal and diseased brain, with a particular focus on the effects of aging and physical activity. We use mouse models and integrate behavioural analysis with quantitative neuroanatomy to study neurogenesis and neurodegeneration. In order to optimise translational value, to increase efficiency and to enable long-term follow-up we build on the fully automated monitoring of mouse behaviour in a social home cage context. For students of HST and other ETH curricula we provide functionally and clinically oriented teaching in anatomy and histology, providing a basis for understanding the relationship between molecular mechanisms, morphological phenotype and function. 

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